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treatment should be discontinued immediately if pregnancy is suspected or confirmed

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In this review, we will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its clinical manifestations (impaired lipid profile, insulin resistance, increased glucose levels, obesity, and cardiovascular disease), discussing whether IGF-1 replacement therapy could be a beneficial strategy for these patients

Similarly, the small molecule activator 2-APQC effectively enhances SIRT3 activity, alleviating cardiac hypertrophy and myocardial fibrosis induced by isoproterenol (ISO)