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This variability is influenced by differences in the permeability of the bloodbrain barrier (BBB) and the bloodcerebrospinal fluid (CSF) barrier, as well as by region-specific expression of enzymes involved in glutathione metabolism

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The crystal structure of human bisphosphoglycerate mutase has been determined, providing a rationale for the specific residues that are crucial for synthase, mutase, and phosphatase activity

Ferroptosis is also characterized by the accumulation of reactive oxygen species (ROS) under high oxidative stress