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The current progress in nanotechnology provides opportunities for overcoming limitations in the treatment of central nervous system disorders, and nanomedicine delivery systems are expected to increase the bioavailability of drugs by enhancing the penetration of drug molecules into the central nervous system and targeting key lesion sites

The disease has been historically linked with limited dietary access among sailors and soldiers in the 15th and 16th centuries

It must be stored in the refrigerator (around 2-8C or 36-46F)

It can occur on the abdomen, chest, back, or limbs

Phlebologie 2003;32:138-42

doi: 10.1016/j.cbd.2021.100941