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[DOI] [PMC free article] [PubMed] [Google Scholar] 220.Berger J.S., Haskell L., Ting W., et al

Apelin protects against ischemia-reperfusion injury in diabetic myocardium via inhibiting apoptosis and oxidative stress through PI3K and p38-MAPK signaling pathways

This bypasses first-pass metabolism in the liver, potentially increasing bioavailability

Thus, its rapid clearance from the blood has been mentioned as a limiting feature

For certain conditions and populations, GHK-Cu is not just inadvisable

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