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Then, to ulteriorly determine how IGF-1 gene overexpression alleviated SIPS of hepatocytes, primary hepatocytes were transfected the IGF-1 adenovirus vector to overexpress IGF-1 (namely AV-IGF-1) or nontarget adenovirus vector (called AV-CTR), and then treated with H 2 O 2 (200 nM) for 24 h

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parkeri evade ubiquitin targeting and antibacterial autophagy via multiple mechanisms, which are required for pathogenesis and causing disease in vivo

As a large protein (approximately 27 kDa), it cannot be synthesized by peptide compounding methods and requires either gene therapy delivery or cell-based manufacturing

[DOI] [PMC free article] [PubMed] [Google Scholar] 118.Perumal M.B., Sah P

This landmark review article comprehensively summarizes biological and technological advancements in four major platforms that accelerated the clinical utility of nucleic acid therapeutics