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Beyond its direct bactericidal effects, LL-37 modulates immune responses and enhances epithelial defense mechanisms

The increased dependence on glutaminase metabolism is associated with mutations in BRAF in melanoma cells [109]

Deranged myocardial fatty acid metabolism in heart failure

The substitution of glycine with alanine at the 15th position is theorized to enhance the peptides bioactivity

By contrast, highly selective reversible inhibitors, such as KDS2010 (~12,500-fold selectivity for MAO-B over MAO-A), demonstrated superior efficacy in mitigating aberrant astrocytic GABA release and oxidative stress without inducing compensatory pathways 543

doi: 10.1016/j.cmet.2018.12.004 50 Batista-GonzalezAVidalRCriolloACarreoLJ