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Description

Intracellular stores of Ca 2+ regulate cellular redox equilibrium by ROS formation and elimination, allowing cells to shift the redox environment towards either a more oxidizing or reducing state

The process involves a complex biosynthesis involving lysine and methionine are converted into L-carnitine

In this context, we note that in a previous study of CSF biomarkers in an independent PD cohort, the metabolites xanthine, homovanillic acid, and their ratio were proposed as biomarkers of PD status and severity 78 , suggesting that xanthine is altered in multiple body fluids in PD and may indeed have diagnostic applications