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This randomized, double-blind, placebo-controlled crossover study, conducted at the University of North Carolina at Chapel Hill, enrolled twenty-five aerobically fit males randomly assigned to ingest six capsules of L-citrulline + GSH (Setria Performance Blend (SPB)) or placebo (PL) one hour prior to exercise for eight days

(ii) cytokine storm-induced immune-metabolic reprogramming, which could elevate kynurenine:tryptophan ratio and trigger chronic depression syndrome 729

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Instead, their therapeutic benefits are mainly brought about by the release of paracrine factors [28, 45, 46]

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10.1097/MOG.0b013e32801b3c8f 114 RitterO.JelenikT.RodenM