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Moreover, diverse extracellular molecular signals, including neurotransmitters, neurotrophins, extracellular matrix proteins, contact-mediated ligands, and secreted diffusible cues, shape neural circuit development and modulate brain connectivity during early life (Hamad et al., 2023)

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This tightly regulated process, influenced by substrate availability, oxygen tension, and cellular energy demand, is crucial for cells with high energy requirements, such as cardiac myocytes, where mitochondria occupy 30% of the cell volume, and neurons, where they are dynamically distributed to synapses