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The approval of tofersen represents a landmark in precision medicine for ALS but also introduces a nuanced paradigm for evaluating efficacy

In these conditions, although total serum vitamin B12 concentrations may appear elevated or apparently normal, tissue vitamin B12 concentrations will be low (Arendt & Nexo, 2012)

Weerts MJ, Sieuwerts AM, Smid M, Look MP, Foekens JA, Sleijfer S, Martens JW

They are found to have an antioxidant effect, according to some studies, they have a range of activities that promote their antioxidant activity, it is suggested that the main pathway is radical scavenging through hydrogen atom donation