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Prog Polym Sci 32:933961 Patel TK, Adhikari N, Amin SA, Biswas S, Jha T, Ghosh B (2021) Small molecule drug conjugates (SMDCs): an emerging strategy for anticancer drug design and discovery

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This mechanism has also been shown to be important in patients with depression in clinical trials

The concern is practical rather than safety-based: receptor desensitization, diminishing returns, and cost

doi: 10.1002/ddr.21726 17

It achieves this by reducing oxidative stress and inflammation, as evidenced by decreased levels of inflammatory cytokines and oxidative markers in lung tissues