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Injections are given subcutaneously (just under the skin), and injection sites should be rotated daily to prevent lipoatrophy or irritation

Additional information Peer review information Nature thanks James Crowe, Gary Nabel and Stanley Perlman for their contribution to the peer review of this work

These over the counter products are a good place to start for patients who have mild pigmentation or skin discoloration

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If youre looking for a peripheral fat-targeted approach and are okay with daily injections, AOD-9604 might seem appealing, but proof of real-world benefit is scarce

Methods Ethical approval All animal experiments reported herein were performed following the guidelines and were approved by Peking University Institutional Animal Care and Use Committee (LA2021316)