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Jarnicki AG, Lysaght J, Todryk S, Mills KH

doi: 10.1038/s41418-021-00859-z 39 KuangFLiuJLiCKangRTangD

The levels vary over the day, decreasing with the uptake of carbohydrates and increasing in periods between meals or because of prolonged muscle work

At a standard therapeutic dose, the majority of the drug is safely converted into inactive, water-soluble compounds via two primary processes: Glucuronidation and Sulfation, which are quickly excreted

The superoxide anions generated during exercise can react with unsaturated fatty acids in the cell membrane, potentially triggering a chain reaction that leads to significant consumption of intracellular GPX4 34

Mediators Inflamm 2023:9810733