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When large (up to 23 L of volume in the case of the liver) and three-dimensional structures are cooled below freezing point, ice can immediately form ( Recent research efforts have taken very different paths, either avoiding ice altogether or aiming to achieve temporal control using novel nature-inspired techniques

doi:10.1038/s41568-019-0149-1 8

doi: 10.1016/S1011-1344(98)00111-0

The hydroxyl groups on quercetins aromatic rings especially at positions 3, 5, 7, and 4 play a critical role in scavenging free radicals

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So far, lungs preserved at 10C have achieved a total clinical preservation time of up to 24 h without negative effects on organ function or short-term outcomes following transplantation