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In addition, NCOA4-mediated ferritin degradation, also known as ferritinophagy, increases the intracellular iron ion levels, promotes lipid peroxidation, and triggers ferroptosis ( Figure 2 Ferroptosis has emerged as a promising target for cancer therapy ( Natural products targeting the iron death signaling pathway affect tumor growth Based on the characteristics of the ferroptosis signaling pathway, natural products that can induce ferroptosis mainly include the following types: 1

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Experiments demonstrated that knockdown of Kdm6A/B or pharmacological inhibition of Ezh2 activity (for instance, using 3-Deazaneplanocin A) could either reverse or mimic the reprogramming effects of miR combo, underscoring the central role of H3K27me3 homeostasis (70,71)