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Subsequently, the activated lipid intermediates are incorporated into phospholipid PUFAs via esterification with phosphatidylcholine by lysophosphatidylcholine acyltransferase 3 (Do and Xu, 2023

Liu GH, Qu J, Shen X (2008) NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

TNF- impairs barrier function by increasing epithelial cell shedding and downregulating occludin expression [78, 79], whereas IFN- increases permeability by inducing STAT1-dependent TJ remodeling [80]

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Cytoplasmic tyramine also activates intracellular trace amineassociated receptor 1 (TAAR1), resulting the phosphorylation of NET, inducing a conformational change of the transporter that results in a reversal of its transport direction

Future studies are warranted to examine the effacacy of AOX therapy in men with high SDF