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The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable

Six trials totaling roughly 900 participants are summarized in Stier et al

We recommend AOD-9604 to help with the early stages of weight loss while simultaneously building healthy habits that promote long-term weight maintenance.

(Neelakantan et al., 2018) observed that systemic administration of NNMTi to mice with diet-induced obesity markedly attenuated WAT mass and body weight, diminished adipocyte volume, and reduced plasma TC levels

This synergy is under exploration in models studying aging, metabolic health, and endurance performance

preliminary evidence exists only for osteoarthritis via intra-articular injection Quick Facts Overview & Origin AOD-9604 (Anti-Obesity Drug 9604) is a 16-amino acid peptide comprising the C-terminal fragment of human growth hormone (hGH), specifically residues 177-191 of the native hormone, with an additional tyrosine residue at the N-terminus