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Although several theories with empirical support tackle the point, the causes of BIPN are multifactorial and not fully understood, it remains a potentially persistent adverse event that can lead to long-term objective neurological dysfunction (Li et al., 2020), thereby reducing the quality of life, weakening physical function, causing delays or dose reductions in chemotherapy, and in some cases even interrupting treatment, imposing a huge economic burden (Selvy et al., 2021)

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Soy-derived phosphatidic acid, lysophosphatidic acid and phosphatidylserine are sufficient to induce an increase in mTOR signaling

Fatty acid oxidation assays were run using glucose (0.5 mM), glutamine (1 mM), 0.5 mM l-carnitine and BSA conjugated palmitic acid

[DOI] [PubMed] [Google Scholar] 619.Mao Q, Unadkat JD

the strongest evidence is class-level extrapolation rather than direct