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342,343,344 Finally, the systemic chronic inflammation resulting from immunosenescence and non-neurotropic viral infection compels immune cells in the peripheral blood to penetrate the blood-brain barrier (BBB) and choroid plexus and enter the brain, 345,346 Additionally, immune cells originating from the cranial bone marrow migrate to the meninges, 347 thereby promoting neuroinflammation and neuronal dysfunction while inhibiting neurogenesis

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