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doi: 10.1038/ni.3772 2 AgarwalS.YadavA.ChaturvediR

The IDO-catalyzed cellular Trp depletion could also explain the IFN--mediated suppression of the mTORC1 activity (Su et al., 2015): mTORC1 is activated by elevated levels of amino acids, especially Leu but also Trp (Hara et al., 1998