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Recent studies have demonstrated that massive A accumulation significantly impairs neuronal integrity through impairment of synaptic function as well as through disruption of the neuronal signaling pathways

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[344] also reported that the use of GA altered the diversity of the gut microbiota and activated the bile acid metabolic pathway, being this fact associated with enhanced ILC3 cells in mesenteric lymph nodes and lamina propria accompanied by reductions in TNF-, IFN-, IL-6, IL-17A, and IL-23, and elevations in IL-10, TGF- and IL-22

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