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Neurotrophins such as nerve growth factor, brain-derived neurotrophic factor and hepatocyte growth factor (HGF) are capable of stimulating dendritic arborization, synaptogenesis, stem cell differentiation, neurogenesis, and decreases in neuroinflammation, oxidative stress-induced damage and neurotoxicity due to a wide range of cellular insults

Other outbreaks have been linked to aerosol (mist) sources in the community or with cruise ships and hotels, with the most likely sources being hot tubs, cooling towers (air-conditioning units from large buildings), and water used for drinking and showering. To prevent the build up of the Legionella bacteria, Occupational Safety & Health Administration (OSHA) recommends that water systems be properly inspected and maintained with frequent flushing of domestic water systems at very high temperatures

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Further advancements, such as incorporating immune components or refining differentiation protocols, will likely bolster the versatility and translational relevance of this promising technology