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Estrogen mutagenicity has also been demonstrated in transfected Big Blue rat2 embyronic cells 26 and Big Blue rats treated with 4-OHE 2 18

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*Correspondence: Igor Allaman, EPFL, SV/ Brain Mind Institute/LNDC, AAB 117, Station 19, CH-1015 Lausanne, Switzerland e-mail: [email protected] This article was submitted to Neuroenergetics, Nutrition and Brain Health, a section of the journal Frontiers in Neuroscience

The first and perhaps most straightforward of these mechanisms is increased mass-specific body oxygen stores which delay the onset of hypoxemia and tissue hypoxia and prolong submergence times (Ponganis et al., 1993

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In a PD animal model, tenuigenin significantly improved motor behavior and reduced dopaminergic neuronal damage by inhibiting the NLRP3 inflammasome (Fan et al., 2017)