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FOXO4-DRI, a novel peptide-based intervention, specifically disrupts the interaction between FOXO4 and P53, thereby inducing apoptosis in senescent cells

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Since the majority of substrates for NADase- CD38 are expected to be intracellular, the ecto-enzymatic activity of this enzyme represents an intriguing topological paradox (Figure 3b)

The addition of grouping variables in PLS-DA can make up for the shortcomings of the PCA method, and the parameter R2X (cum) can be used to judge the validity of the model.PLS-DA In addition to the parameter R2X (cum), it also includes the explanation rate R2Y (cum) and the prediction rate Q2 (cum), and the closer the two are to 1, it means that the PLS-DA model can better explain and predict the differences between the two groups of samples, which represents the better the model prediction ability

(2006[110]) explored phenolics i.e