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Based on the findings, the mixtures of glabridin:resveratrol, glabridin:oxyresveratrol, resveratrol:oxyresveratrol, phenylethylresorcinol:resveratrol 441 , oxyresveratrol:dioscin 442 , aloesin:arbutin 443 , 4-methyl catechol: catechol 444 , 3-(2,4-dihydroxyphenyl)propionic acid:l-ascorbic acid 445 , dihydromyricetin:vitamin D3 37 , linderanolide B combined with arbutin, 1-phenyl-2-thiourea or kojic acid 446 , have shown synergistic effect on tyrosinase