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Molecules, 25 (21)

This suggests that the pathological processes and tissue damage established over years of CFTR dysfunction may not be entirely reversible by the current levels of CFTR correction achieved, or that the restoration of CFTR function is insufficient to fully extinguish these self-perpetuating cycles of inflammation and oxidative damage

doi: 10.3390/microorganisms8122018 51 KolodziejczykA

doi: 10.1016/j.ctcp.2016.11.008 149 ChenJGuoQY-HPRenQ-LChiLHuR-Ket al

Conservative treatments are often effective and may include: Anti-inflammatory medications to reduce pain and inflammation Rest and activity modification to relieve pressure on the sciatic nerve Ice or heat to relax tight muscles Injections such as steroid or platelet-rich plasma (PRP) to reduce pain and promote healing Physical therapy to correct muscle imbalances and restore normal function Surgical treatment may be considered if conservative measures fail: Decompression of the sciatic nerve Piriformis muscle release Neurolysis of the sciatic nerve Recovery from surgery typically takes several weeks to a few months, depending on the procedure performed and the individual patient

European journal of obstetrics, gynecology, and reproductive biology