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In a healthy brain, microglia maintain a dynamic balance between protective, anti-inflammatory functions and detrimental, pro-inflammatory signaling [1, 3, 4]

You experience frequent illness and want to strengthen your immune defenses

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Selenium enhances the bodys antioxidant capacity by participating in the synthesis of various selenoproteins, such as the glutathione peroxidase and thioredoxin reductase families

Since glutathione also helps support mitochondrial function, lower levels may affect how efficiently cells produce energy

For instance, deletion of one SOD allele in transgenic mice over-expressing -APP accelerated the onset of behavioural changes and A plaques in brain parenchyma, but increased the development of cerebrovascular amyloidosis, gliosis, and neuritic dystrophy