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doi: 10.1016/J.MCNA.2006.07.009 38 DahalR

Pregnant or breastfeeding women, minors, and anyone seeking medical treatment for injury must avoid it entirely

Phase I metabolism of the alkaloids involved hydrolysis of the methyl ester of the acrylic acid group at C-16, O -demethylation of the methoxy group at C-9 and C-17 positions, followed by oxidation to carboxylic acid or reduction to alcohol (Table 1