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J Membrane Biol

Arsenic metabolism in plants: an inside story

152,153 Moreover, intracellular copper can stabilize the biochemical structure of transcription factor HIF-1 and enhance the activity of the nuclear factor NF-B, thereby ensuring their transcriptional activity on angiogenesis genes such as VEGF and ceruloplasmin and promoting the expression of angiogenic mediators including FGF2, VEGF, IL-8, IL-6, and IL-1