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10.1038/s41598-024-57580-3 41 Lorenzo-AlmorsA.TunJ.OrejasM.CortsM.EgidoJ.Lorenzo

Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer

These results highlight a novel intestinal mechanism underlying metformins efficacy and provide insights for potential therapeutic strategies beyond traditional glucose regulation

However, under zinc excess, lysosomal destabilization and leakage of cathepsin D into the cytosol can trigger mitochondrial damage and apoptosis via the lysosomemitochondria axis 168