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Normal methylation cycles absolutely depend upon adequate levels of vitamin B12 as well as other key nutrients such as folate, riboflavin, B6, niacin, magnesium, and zinc

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Some more stable peptides can last 4-6 weeks, while fragile ones may show significant degradation by week 2

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Conversion of Hcy to Met by MS depends on the availability of both vitamin B 12 and folate (as N 5 -CH 3 -THF), and therefore, nutritional deficiencies in either one of these micronutrients lead to the accumulation of Hcy in serum and urine