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However, the combination of these elements in a single transgene yielded very low levels of -globin gene expression in the erythroid cells of mice undergoing transplantation with genetically modified HSCs bearing the transgene [122], [123], [124]

FS: Writing review & editing

This work was financially supported by the Medical University of Biaystok (B.SUB.23.325 to TD)

The current understanding is based on their separate mechanisms of action, which do not appear to directly conflict

Therefore, ATRA-ATO-NPs could greatly enhance the synergistic inhibition of ATRA and ATO on PIN1 expression in cancer cells, consistent with the above experimental results