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But injections of hyaluronic acid might also be indicated in individuals with: Intolerance or contraindications to nonsteroidal anti-inflammatory drugs (NSAIDS) Patients who are poor surgical candidates Chondrocalcinosis Any type of cartilage injury Clinical evidence shows support for using intra-articular hyaluronic acid in individuals intolerant to NSAIDS and those wishing to defer or not willing to undergo surgery

Interestingly, in chronically insulin treated 3T3-L1 cells and fat explants from insulin resistant mice, only insulin-stimulated glucose uptake is decreased while insulin suppression of lipolysis is intact (121), effects which are explained by selective insulin resistance in adipocytes