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Common side effects Mild and transient: Headache (most common) Nasal irritation (intranasal route) Drowsiness or fatigue Mild dizziness Dry mouth or throat These effects typically resolve within hours and often diminish with continued use as tolerance develops

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Data availability Source data underlying graphs presented in the main figures can be found in Supplementary Data 1 and are available from the corresponding author on reasonable request

Other available forms of vitamin B 12 include hydroxocobalamin and the two active forms, adenosylcobalamin (cobamamide) and methylcobalamin

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