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618 In 2019, LNPs formulated with 306-O12B-3/cholesterol/DOPE/DSPE-PEG2000 at a ratio of 16:4:1:1 (w/w) were used to deliver ASOs targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) in mice, resulting in significant PCSK9 silencing with the ED 50 as low as 0.034 mg/kg following systemic administration

In vitro metabolic zonation through oxygen gradient on a chip

Glucocorticoids are among the most commonly prescribed medications for retinal diseases, with the primary treatment method being intravitreal injections, delivering drugs directly into the vitreous to exert anti-inflammatory, immunosuppressive, and vasoconstrictive effects [320,321,322]

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Dietary sugars and endogenous formation of advanced glycation endproducts: emerging mechanisms of Disease[J]

Self-renewing macrophages in dorsal root ganglia contribute to promote nerve regeneration