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Nevertheless, how mTORC1 and mTORC2 interact with their substrates at different cellular locations and how compartment-specific signaling contributes to distinct physiological outcomes are still unclear

Visualization was done with a Laser Scanning Confocal Microscope (Olympus, Tokyo, Japan)

For instance, tocotrienols (especially -tocotrienol) have shown greater anti-proliferative and pro-apoptotic effects than tocopherols in malignant cell lines (13)

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