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Acta 126 LyttleM

J., Flammer, A

46 Despite the growing progress in AAV-mediated cardiac gene therapy, challenges remain to overcome host neutralizing anti-AAV antibodies, AAV delivery methods, and large-scale manufacture of AAV which will facilitate AAV cardiac gene therapy in large animal models and promote the translation to clinical application in the future

For example, it is feasible that both mitochondrial and nuclear compartmentalization of redox signaling exists, and this could be important in exercise-induced changes in redox signaling in muscle fibers (140)

However, the delivery of the drug in the coated NLCs form led to the degeneration of larvae, with less intense inflammatory changes observed

6 (11th ed.)