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OS leads to irreversible macromolecular changes in addition to the disruption of normal cellular signalling

Keep antihistamines available during the transition period

This is where alternative delivery systems, specifically intranasal sprays, have started capturing serious attention

In a randomised controlled clinical trial, administration of a recombinant canarypox virus expressing feline IL-2 was well tolerated and resulted in a significantly longer median time to relapse and a significant reduction in the risk of relapse at one year and two years (Jas et al., 2015)