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The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function

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Specifically, suppression of the 7-nAChR/cAMP/PKA/CREB signaling pathway, reserpine promoted microglial polarization of microglia toward the M1 phenotype and induced neuronal apoptosis, thereby altering neural plasticity (120).Activation of Nrf2 acts as a critical bridge for inhibiting the p38 MAPK pathway, while CREB activation competes with NF-B for limited coactivators, thereby suppressing the expression of pro-inflammatory gene expression

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doi: 10.1016/j.archoralbio.2021.105340 39