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Ethanol may have the capacity to elevate the activity of nicotinamide adenine dinucleotide phosphate oxidase (NOX) or NADPH Oxidase enzymes, which, in turn, can lead to the formation of ROS [180]

Moreover, we have recently reported that peripherally administered NPW alleviates colonic inflammation, and protects against sepsis-induced oxidative multiorgan injury (Atici et al

S7), indicating that, in addition to maintaining -cell identity, FoxO1 might directly regulate insulin expression