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A method of preventing weakness in a patient with Parkinson's disease or of improving or restoring muscle strength of a patient with Parkinson's disease, comprising the step of administering to said patient an amount of one or more hepatocyte growth factor mimics sufficient to prevent, improve or restore to normal said muscle strength, said one or more hepatocyte growth factor mimics having a general structural formula 1 2 3 where R] is one of an N-acyl group, a substituted or unsubstiruted phenyl, a norleucine group, and an amino acid selected from tyrosine, phenylalanine, aspartic acid, arginine, isoleucine, serine, histidine, glycine, cysteine, methionine, tryptophan, lysine norvaline, ornithine, and s-benzyl cysteine

10.3389/fphar.2021.693983 59 ZhouX.WangG.WangX.LiuL.ZhangQ.YinY.et al (2017)

10.1186/s13027-017-0145-6 17 ChenJ.WangY.WuJ.YangJ.LiM.ChenQ

Lunetta C, Serafini M, Prelle A, Magni P, Dozio E, Ruscica M, Sassone J, Colciago C, Moggio M, Corbo M: Impaired expression of insulin-like growth factor-1 system in skeletal muscle of amyotrophic lateral sclerosis patients

J.FearonE

Nevertheless, the underlying precise regulatory mechanisms require further elucidation