Thus, in the CRC TME, three factors synergize to form an extensive immunosuppressive network: Trp depletion driven by excessive IDO1/TDO2 activity, massive kynurenine (Kyn) accumulation, and elevated 5-HT levels resulting from Trp shunting into 5-HT synthesis
Reactive oxygen species as oxidants and signaling molecules have a fundamental influence in almost all biological processes (Shaikhali et al., 2012

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The stability of folic acid may be improved not only by encapsulation but also by the synthesis of some derivatives
BP, biological process
New York, NY: Oxford University Press (2014)