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Dihexa induces spinogenesis in cultured hippocampal neurons Actin-enriched spines increased in number in response to both dihexa (Figure 38B&D) and Nle'-AnglV (Figure 38C&D) following 5 days of treatment at 10 "12 M concentration that started on the 7 th day in vitro (DIV7) the results revealed a near 3-fold increase in the number of spines stimulated by dihexa and greater than 2-fold increase for Nle f -AngIV

DIC and fluorescent images (488 bandpass filter) were captured

Different readings correspond to different physical effects

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Often the final prize is an invitation to apply to a tailored SBIR Phase I or Phase II, making xTech one of the more direct on-ramps to Army SBIR funding available to small businesses