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Konopleva M, Cortes J, S-C C, Hayes K, Giles F, OBrien S, Kantarjian H, Andreeff M , Estey E

doi: 10.1182/blood.V90.8.3187 75 MendesMAde CarvalhoDSAmadeuTPSilvaBPrataRda SilvaCOet al

( Punica granatum methanolic pulp and peel extracts, which are rich in anthocyanins including cyanidin, delphinidin, and malvidin, were administered in male mice at doses of 25 and 50 mg/kg along with fluoxetine as the standard drug (20 mg/kg), respectively

Review of prior outpatient testing revealed a possible episode of ventricular tachycardia while having an IV placed for a tilt table test, to rule out Postural Orthostatic Tachycardia Syndrome (POTS) so she was sent for a cardiology evaluation and cardiac stress test, which showed normal myocardial perfusion and no significant cardiac abnormalities

The residues involved in this pocket, specifically Q61, underlie the mutational preferences of Affimer K3 for wild-type/G12 mutants vs

However, inflammatory outcomes varied depending on the experimental model and biomarkers evaluated