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[156] Aside from overloading endogenous CCSdependent and independent metalation pathways, [154] disproportionately high SOD1 expression may create a mismatch between Cu demand and supply in the brain and spinal cord, where Cu import is much less efficient than in the periphery.[ 134 , 157 ] This may contribute to SOD1 mismetalation and partially underlie the reduction in SOD1 specific activity (SOD1 enzymatic activity per unit of protein) observed in transgenic mutant SOD1 mice

The cytosolic MG is converted to SLG by SbGLYI-10 and/or SbGLYI-11 which is then further converted to D-lactate by SbGLYII-3

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2012 Jun 1

10.1016/j.envexpbot.2018.02.001 74 LiuP