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156 Another peptidomimetic analogue, TLK117, has been extensively investigated in the context of lung fibrosis

For drug combination experiments, serial dilution of CB839 (Selleckchem) or MSO (Sigma) at concentrations above was performed in the presence or absence of sublethal doses of MSO (2 mM) or CB839 (100 nM), respectively

They are often used together within a personalized pathway

10.1126/science.1207745 237

However, the result is not the same for everyone, and the effect goes away when you stop the treatment

For example, patients often have lower levels of anti-inflammatory bacteria such as Faecalibacterium and higher proportions of pro-inflammatory species, which may contribute to systemic inflammation and symptom severity (Knig et al., 2021