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SKU: 33988021656
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Preclinical toxicology has not identified a clear safety signal at commonly studied doses in animal models, but absence of evidence is not evidence of safety in humans

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This experiment shows that the inhibitory capacity of 1a R -IN-8 directly depends on JNK ATP-pocket engagement in cells, as expected from a JNK-specific ATP-competitive inhibitor

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Nevertheless, when combining CB-839 with venetoclax and AZD-5991, there was a significant drop in other OCR parameters such as basal OCR, maximal OCR, and spare respiratory capacity when compared to monotherapy