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Induction of lysosomal exocytosis and biogenesis via TRPML1 activation for the treatment of uranium-induced nephrotoxicity

Many zinc supplementation studies have been performed and reviewed [114,144,145]

Selenium intake from the diet can enter cells through the endocytosis of selenium-containing carrier protein selenoprotein P, which is secreted by the liver

FUS is known to interact with HSP60, which is associated with mitochondrial abnormalities, and these defects have been identified in FUS-FTLD patients (Deng et al., R495X dysregulates the expression of genes associated with oxidative mitochondrial metabolism in neurons, and significantly reduces the size of mitochondria, which induces neurotoxicity (Nakaya and Maragkakis, 2018)

This remains an area of active research rather than established clinical practice, and until adequately powered, randomised controlled trials assess the safety and efficacy of this specific combination, clinicians and patients should approach any claims about its benefits with appropriate scepticism

The key features for probes is that they must be an adequate size to assess the route of permeability being assessed and freely filtered into urine where they can be measured