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Studies have indicated that editing the ApoE4 allele to the ApoE3 allele via gene-editing technologies leads to a reduction in ApoE fragmentation, A production, tau phosphorylation, and GABAergic neuron degeneration in iPSC-derived neurons, suggesting that the detrimental effects of ApoE4 could be alleviated through gene editing (Yamazaki et al., 2019

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