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[DOI] [PMC free article] [PubMed] [Google Scholar] Pagano C, Calarco P, Ceccarini MR et al

The peptide contains an N-terminal acetylation that differs from the naturally occurring form

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The full thymosin beta-4 molecule has been studied for its role in cell migration, angiogenesis, and wound repair (Goldstein et al., Expert Opinion on Biological Therapy, 2012)

(2) the ability of the TJ to selectively allow paracellular transport of certain ion species acting as ion channel and (3) the ability of the TJs to maintain cell polarity, by blocking the free diffusion of proteins and lipids between the apical and basolateral domains of the plasma membrane

Three other CD38 binding antibodies are in clinical trials: Isatuximab (Sanofi-Aventis), MOR202 (Morphosys), and TAK079 (Takeda) (Table 2) [42, 48-49, 64]